This study aimed to design and validate a native model of an empowering entrepreneurial ecosystem for female-headed households in the 22 districts of Tehran metropolis. The research adopted a developmental-applied purpose with a sequential exploratory mixed-method design. In the qualitative phase, semi-structured interviews were conducted with 30 experts, including entrepreneurship management professors, Tehran municipality managers, activists from non-governmental organizations, and successful female entrepreneurs. In the quantitative phase, 380 female-headed households and female entrepreneurs residing in Tehran were selected through multi-stage cluster sampling from five selected districts (3, 6, 12, 15, and 22) and completed a researcher-developed questionnaire. Reliability was confirmed with Cronbach's alpha (0.86) and composite reliability (0.94). Data analysis was performed using Structural Equation Modeling with Partial Least Squares approach (PLS-SEM).The final model was organized into three levels. The first level (foundational/supportive) includes five components: individual factors, social support, access to resources, institutional factors, and market and opportunities.The second level (performance pathway) includes entrepreneurial intention, business creation, and business performance.